Antiviral activity of medicinal plants against human coronavirus: systematic scoping review and experiments

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J Tradit Chin Med. Jun 2022;42(3):332-343. doi: 10.19852/j.cnki.jtcm.2022.03.002.

ABSTRACT

OBJECTIVE: To investigate and investigate natural compounds and medicinal plants with anti-coronavirus activity.

METHODS: A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research: Guidelines for Reporting Experiments to Find Data on Herbal Medicines and Natural Products effective against human coronaviruses in or studies. Studies published up to September 6, 2020 were included. Studies ( or ) reporting the effect of herbal and natural products or their derivatives on human coronavirus were included Severe acute respiratory syndrome coronavirus (SARS-CoV); Hirstenone, the six cinnamic amides and bavachinin are PLpro inhibitors and tanshinones are active on both 3CLpro and PLpro. Certain citrus flavonoid compounds act on immunoregulation and target the angiotensin-2 converting enzyme which is used by SARS-COV for entry. Viral helicase is possibly inhibited by two compounds, myricetin and scutellarein.

CONCLUSION: This review shows that complementary medicine has the potential to discover new drugs against the coronavirus. More research is needed before any firm conclusions can be drawn regarding the safety and effectiveness of using these herbal medicines.

PMID:35610002 | DOI:10.19852/j.cnki.jtcm.2022.03.002

Alvin J. Chase