Effects of herbal medicines and natural compounds in sex steroid models of prostate cancer: a systematic review

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Phytother Res. 2022 May 23. doi:10.1002/ptr.7498. Online ahead of print.


Prostate cancer remains a health problem for men. Targeting androgen (AR) and estrogen (ER) receptors improves disease outcomes, and many herbal remedies exert their effects by modulating these pathways. Therefore, a systematic review was conducted to identify medicinal plants and their natural compounds that may modulate AR and/or ER pathways in cellular and animal models. A search was conducted in EMBASE, LILACS, PubMed, Scopus and Web of Science, with gray literature from Google SCHOLAR and ProQuest. Two authors independently selected eligible studies based on their titles and abstracts, and a third author resolved conflicts. Then, full-text data from eligible studies were extracted and synthesized. A total of 75 studies were included. The results showed the effects of several different medicinal plants and natural compounds on the reduction of AR and/or ER transcription and translation and AR side effects: reduction of cell growth, induction of apoptosis and cycle arrest. cellular. In animal models, reduction in tumor size, increased apoptosis and downregulation of AR expression in tumors were also observed. No single phytochemical group concentrating molecules with anti-AR and/or ER activity has been identified. Nevertheless, several phytochemicals have shown potential for future clinical studies in disease management.

PMID:35605997 | DOI:10.1002/ptr.7498

Alvin J. Chase