Medicinal plants with potentially inhibitory bioactive compounds against coronaviruses

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Adv Pharm Bull. Jan 2022;12(1):7-16. doi: 10.34172/apb.2022.003. Published online January 30, 2021.


The medicinal plant is a major source of drug discovery for disease management. Over 85% of the population in Asia and the Middle East use herbal medicine for the management of illnesses such as Severe Acute Respiratory Syndrome (SARS) caused by the coronavirus. Coronavirus infection is triggered by entry of the virus into a susceptible host cell. Two decades ago, the two human coronaviruses of public health importance were SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) and now SARS-CoV-2. These three viruses belong to the same beta-coronavirus class and are somewhat similar in genome sequencing, life cycle, mode of entry into a host, mode of transmission, and clinical manifestations. This review identified twenty herbal medicines with potential inhibitory bioactive compounds from natural sources that are active against coronaviruses that could be developed in various drug delivery systems. He also highlighted several pieces of evidence to show that the herbal medicine used in the treatment of SARSCoV can offer some sort of relief from the burden of the coronavirus disease 2019 (COVID-19) pandemic. Since there is no specific treatment for COVID-19 yet, the search for herbal medicines containing bioactive compounds that are inhibitory against the coronavirus could be the breakthrough scientists have long awaited to change the narratives of the COVID-19 pandemic. 19.

PMID:35517886 | PMC:PMC9012928 | DOI:10.34172/apb.2022.003

Alvin J. Chase